Radiation-gene therapy, a dual anticancer strategy of radiation therapy and gene therapy through connecting radiation-inducible\nregulatory sequence to therapeutic gene, leading to the gene being induced to express by radiation while radiotherapy is performed\nand finally resulting in a double synergistic antitumor effect of radiation and gene, has become one of hotspots in the field of cancer\ntreatment in recent years. But under routine dose of radiation, especially in the hypoxia environment of solid tumor, it is difficult\nfor this therapy to achieve desired effect because of low activity of radiation-inducible regulatory elements, low level and transient\nexpression of target gene induced by radiation, inferior target specificity and poor biosecurity, and so on. Based on the problems\nexisting in radiation-gene therapy, many efforts have been devoted to the curative effect improvement of radiation-gene therapy\nby various means to increase radiation sensitivity or enhance target gene expression and the expression�s controllability. Among\nthese synergistic techniques, gene circuit, hypoxic sensitization, and optimization of radiation-induced sequence exhibit a good\napplication potential. This review provides the main influential factors to radiation-gene therapy on cancer and the synergistic\ntechniques to improve the anticancer effect of radiation-gene therapy.
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